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A benfotiamine-vitamin B
combination in treatment of diabetic
polyneuropathy.
Stracke H, Lindemann A, Federlin
K.
Third Medical Department, University of Giessen,
Germany.
In a double-blind, randomized, controlled study, the
effectiveness of treatment with a combination of Benfotiamine (an
Allithiamine, a lipid-soluble derivative of vitamin B1 with high
bioavailability) plus vitamin B6/B12 on objective parameters of
neuropathy was studied over a period of 12 weeks on 24 diabetic patients
with diabetic polyneuropathy. The results showed a significant
improvement (p = 0.006) of nerve conduction velocity in the peroneal
nerve and a statistical trend toward improvement of the vibration
perception threshold. Long-term observation of 9 patients with verum
over a period of 9 months support the results. Therapy-specific adverse
effects were not seen. The results of this double-blind investigation,
of the long-term observation and of the reports in the literature
support the contention that the neurotropic benfotiamine-vitamin B
combination represents a starting point in the treatment of diabetic
polyneuropathy.
Publication Types:
- Clinical Trial
- Randomized Controlled Trial
PMID: 8886748 [PubMed -
indexed for MEDLINE]
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