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* The chemical name and formula for benfotiamine is: S-benzoylthiamine-O-monophosphate (C19H23N4O6PS) . Benfotiamin & benfothiamine are synonyms for benfotiamine, however "benfotiamine" is currently the most frequently used common name for this compound.
View Benfotiamine Molecule
The original patent for benfotiamine, filed in 1962 (now expired), can be viewed in Adobe Reader (*.pdf) format below:
Benfotiamine Patent No. 3064000 (four pages, total).

If you don't have Adobe Reader, you may download a free copy at this link:

If you prefer to view the patent at the USPTO site, you may initiate your own search by clicking below and in "search term 1" use: "3064000"; corresponding to "field 1": "patent number," then be sure to "select years": "1790 to present."
USPTO Quick Search Page.
VITAMIN B1 (Thiamine) What does it do? Vitamin B1 is needed to process carbohydrates, fat, and protein. Every cell of the body requires vitamin B1 to form the fuel the body runs on—ATP. Nerve cells require vitamin B1 in order to function normally.

Where is it found? Wheat germ, whole wheat, peas, beans, enriched flour, fish, peanuts, and meat are all good sources of vitamin B1.

Vitamin B1 has been used in connection with the following conditions (refer to the individual health concern for complete information):

Rating Health Concerns
Three Stars Anemia (for genetic thiamine-responsive anemia)
Two Stars Alzheimer’s disease
Canker sores
Childhood intelligence (for deficiency)
Dialysis (for encephalopathy and neurologic damage; take only under medical supervision)
Low back pain (in combination with vitamin B6 and vitamin B12)
One Star Cardiomyopathy (only for wet beri beri)
Dysmenorrhea (painful menstruation)
HIV support
Multiple sclerosis
Pre- and post-surgery health
Three Stars: Reliable and relatively consistent scientific data showing a substantial health benefit.
Two Stars: Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
One Star: An herb is primarily supported by traditional use, or the herb or supplement has little scientific support and/or minimal health benefit.

Who is likely to be deficient? A decline in vitamin B1 levels occurs with age, irrespective of medical condition.1 Deficiency is most commonly found in alcoholics, people with malabsorption conditions, and those eating a very poor diet. It is also common in children with congenital heart disease.2 People with chronic fatigue syndrome may also be deficient in vitamin B1.3 4 Individuals undergoing regular kidney dialysis may develop severe vitamin B1 deficiency, which can result in potentially fatal complications.5 Persons receiving dialysis should discuss the need for vitamin B1 supplementation with their physician.

Can I take too much? Vitamin B1 is nontoxic, even in very high amounts.

Are there any interactions with other nutrients? Vitamin B1 works hand in hand with vitamin B2 and vitamin B3. Therefore, nutritionists usually suggest that vitamin B1 be taken as part of a B-complex vitamin or other multivitamin supplement.

Are there any drug interactions? Certain medications may interact with vitamin B1. Refer to the drug interactions safety check for a list of those medications.


1. Wilkinson TJ, Hanger HC, George PM, Sainsbury R. Is thiamine deficiency in elderly people related to age or co-morbidity? Age Ageing 2000;29:111–6.

2. Shamir R, Dagan O, Abramovitch D, et al. Thiamine deficiency in children with congenital heart disease before and after corrective surgery. JPEN J Parenter Enteral Nutr 2000;24:154–8.

3. Heap LC, Peters TJ, Wessely S. Vitamin B status in patients with chronic fatigue syndrome. J R Soc Med 1999;92:183–5.

4. Grant JE, Veldee MS, Buchwald D. Analysis of dietary intake and selected nutrient concentrations in patients with chronic fatigue syndrome. J Am Diet Assoc 1996;96:383–6.

5. Hung SC, Hung SH, Tarng DC, et al. Thiamine deficiency and unexplained encephalopathy in hemodialysis and peritoneal dialysis patients. Am J Kidney Dis 2001;38:941–7.

6. Cheraskin E, Ringsdorf WM, Medford FH, Hicks BS. The “ideal” daily vitamin B1 intake. J Oral Med 1978; 33:77–9.